Contact us

Carson Merkwan

Carson@MainStreetInnSD.com

1-605-464-1667

221 East Main Street
Vermillion, SD 57069

Hours of operation


Open everyday
Check for Availability

This building has stairs and no elevator.

Check in is 3 p.m. Check out at Noon.

Tell us when you want breakfast in the morning and what allergies/food preferences you may have. We will try to accommodate.

Rooms are less expensive on the weekdays.

Renting out the whole facility for reunions, small weddings, business events, and game days are great ideas to take advantage of this bed and breakfast's set up to enjoy your family and friends.

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Established in the year 2021

A 7,000 square foot renovated Fraternity house, brought to you by the locals of Vermillion in a classic craftsman style.

Relax and have a good time.

Our Rooms are larger than hotel rooms and all have their own private bathrooms. Bathrooms have heated floors and soft water showers. The rooms have custom Amish furniture. Warm craftsman's style trim work with solid oak. Great Wi-fi. Ethernet ports. Big televisions. USB and wireless phone chargers. Secure electronic locks. Outdoor cameras on your car. Comfort stations with complimentary snacks and drinks, refrigerators, microwaves, sink, coffee, and RO filtered water.